SCPA063 March 2023 PCA9306
When two buffers are connected together, the buffers never be placed in a configuration such that their static voltage offsets are connected together. If connected together, the static voltage offsets of each buffer influences the internal logic structures of both devices, and prevents a low from propagating to the controller when the target device pulls low. To avoid this issue, never connect two buffers together by their buffered sides. See the Why, When, and How to use I2C Buffers application note for an overview of the different acceptable connection configurations of buffers.