This application note explains and demonstrates two different over-current protection mechanisms that the different eFuse devices provide. One is called current-limit, and another is circuit-breaker. Using experimental results, this article also discusses the limitations of the current-limit-based over-current protection in enterprise server applications, where the power delivery system is exposed to high slew-rate, high frequency, and high amplitude load transients. The limitations of the approach as mentioned above are solved through the circuit-breaker mechanism along with a programmable over-current blanking timer in TI’s high-current eFuse family of devices. This design is discussed in this application note through experimental results. The system-level benefits of using TI’s high-current eFuse design over the conventional eFuse devices available in the market are also discussed.