This reference design demonstrates the analog capabilities of the MSPM0L1306 in a low-cost, single-chip pulse oximeter design. The operational amplifiers (OPAs) within the MSPM0L1306 serve as the trans-impedance amplifier (TIA) and current control driver with zero-drift, low-noise capabilities. The integrated high-speed, analog-to-digital converter (ADC) provides the ability to oversample and achieve high levels of dynamic range. This design features a GUI to visualize photoplethysmography (PPG) waveforms and vitals measurements of heart rate in beats per minute (BPM) and peripheral oxygen saturation (%SpO₂).