Another option you have with integrated multiplexers or switches is optimized layout and control. Most analog switches are GPIO CMOS input control which already has advantages over LED input controls like photorelays. But this can be further be optimized with SPI controlled devices like the TMUXS7614D. As seen in the previous example, if you are trying to control a 16 channel system, you normally need 16 GPIO controls or 16 LED drive channels for an analog switch and photorelay respectively. With a SPI controlled multiplexer, the control can be connected in daisy chain, meaning you only need 3 control lines (clock, data, chip select) to control all 16 channels independently. And this can be scaled up to any channel count, with only 3 control pins.

Additionally, the TMUXS7614D integrates the decoupling capacitors and has an optimized layout so the routing and placement can be done with minimal empty space around the switch. This enables a much higher effective channel density when routing is considered.