SLLA551 March 2022 TUSB216I , TUSB217A
The SDA and SCL/CD pins have not changed from the TUSB212 to the TUSB216I. Installing 4.7-kΩ pullups to 3.3 V (or 2-kΩ pullups to 1.8 V for the TUSB216I) enables I2C mode in both TUSB212 and TUSB216I. If the redriver is not configured to use I2C, these pins can be left unconnected.
TI recommends to connect the SCL/CD signal to a test point on the PCB, so the CD output can be used for debug if needed.