The ISO154x devices are low-power, bidirectional isolators that are compatible with I²C interfaces. The logic input and output buffers on these devices are separated by TI’s Isolation technology utilizing a silicon dioxide (SiO₂) barrier. When used in conjunction with isolated power supplies, these devices block high voltages, isolate grounds and prevent noise currents from entering the local ground and interfering with or damaging sensitive circuitry.

The ISO1540 has two isolated bidirectional channels for clock and data lines and is fit for multi-master applications. The ISO1541 has a bidirectional data and a unidirectional clock channel and is useful in applications that have a single master.

These devices achieve isolated bidirectional communication by introducing an offset, making the side 1 low-level output greater than the side 1 low-level input and thus preventing an internal logic latch that otherwise would occur with standard digital isolators.