The Safety and Security Unit (SSU) is an integrated module in C29x devices that enables run-time functional safety and cybersecurity protections for application code. The features of the SSU enable robust Freedom from Interference (FFI), secure task isolation, debug security and firmware update protections in hardware, maintaining low-latency performance needed for real-time control systems. The SysConfig tool, provided as part of the MCU SDK, provides an easy-to-use graphical user interface (GUI) for configuring the SSU and enabling safety and security protections in user applications. This application note examines the various features of the SSU, and how embedded system developers can use the SysConfig to design and implement run-time safety and security in real-time applications.