PCI-Express (or PCIe) 5.0 links provide an overall loss budget of 36dB at 16GHz. Unsurprisingly, many systems have PCIe links that exceed the loss budget, imperfect implementations that reduce the available loss budget, or both. TI PCIe Gen5 redrivers with integrated signal conditioning can reduce deterministic jitter caused by channel losses, increase the loss budget, and ultimately increase the reach of PCIe 5.0 links by up to 45%. This application note provides guidance on using the DS320PR810 and DS320PR1601 for better signal integrity and reach extension. PCIe is also applicable for related devices such as the SN75LVPE5421 and SN75LVPE5412 with integrated multiplexers and de-multiplexers, respectively.