This user's guide assists with migrating from the NXP's Arm® Cortex®-M0+ MCU platform to the Texas Instruments Arm Cortex-M0+ MSPM0 MCU ecosystem. This guide introduces the MSPM0 development and tool ecosystem, core architecture, peripheral considerations, and software development kit. The intent is highlight the differences between the two families and to leverage existing knowledge of the NXP Arm Cortex ecosystem to quickly ramp with the MSPM0 series of MCUs.